Hematopoietic transcriptional mechanisms: From locus-specific to genome-wide vantage points

A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

BACKGROUND Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common and rare copy number variants (CNVs) potentially affect the function of genes and may influence disease risk. AIM To identify CNVs associated with osteoporotic bone fracture risk. METHOD We performed a g...

Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data

Transcription factors are key regulators of both normal and malignant hematopoiesis. Chromatin immunoprecipitation (ChIP) coupled with high-throughput sequencing (ChIP-Seq) has become the method of choice to interrogate the genome-wide effect of transcription factors. We have collected and integrated 142 publicly available ChIP-Seq datasets for both normal and leukemic murine blood cell types. ...

Characterizing the Internet Hierarchy from Multiple Vantage Points

About the Talk The delivery of traffic through the Internet depends on the complex interactions between thousands of Autonomous Systems (ASes) that exchange routing information using the Border Gateway Protocol (BGP). This talk investigates the topological structure of the Internet in terms of customer-provider and peer-peer relationships between ASes, as manifested in BGP routing policies. We ...

Mapping Partially Observable Features from Multiple Uncertain Vantage Points

In this paper we present a technique for mapping partially observable features from multiple uncertain vantage points. The problem of concurrent mapping and localization (CML) is stated as follows. Starting from an initial known position, a mobile robot travels through a sequence of positions, obtaining a set of sensor measurements at each position. The goal is to process the sensor data to pro...

Spatial Judgments from Different Vantage Points: A Different Perspective